Development of a Site Specific & Versatile Conjugation Approach Based On Bacterial Transglutaminase & the Diels-Alder Cycloaddition Reaction for ADCs
- The versatility of maleimides for the conjugation to antibodies – a different application that specifically conjugates via cycloaddition reaction vs conjugation to interchain disulfides or engineered cysteines
- Design and synthesis of the diene-containing linkers for site specific transglutaminase conjugation for two different payloads
- Evaluation of the in vitro and in vivo activity and stability of the ADCs generated via this transglutaminase – Diels-Alder approach