Roundtable Discussion: Balancing Linker Stability & Payload Release in ADCs for an Optimal Therapeutic Index
- Exploring how to balance chemical modifications for stability while maintaining effective release kinetics of the payload
- Exploring strategies to optimize linker stability under physiological conditions, focusing on factors such as pH and temperature for controlled cleavage
- Highlighting case studies and design modifications to enhance cleavable linker stability without compromising therapeutic efficacy