Andrea North

Choosing the ideal conjugation site is critical for maximizing ADC stability and ensuring efficient release at the target site. This workshop will explore how

strategic conjugation site selection can enhance linker durability and improve ADC performance.

This workshop will cover:

• Understanding the influence of the chemical environment on conjugation site selection to improve hydrophobicity control
• Leveraging structural modeling and analytical tools to explore viable conjugation sites
• Balancing linker exposure to prevent premature cleavage while ensuring efficient release at the target site
• Exploring the impact of different conjugation chemistries (e.g., beta-glucuronidase, thiomaleimide) on site accessibility and stability
• Using hydrophobicity profiling and hydrophobic interaction chromatography to assess linker exposure