Francisco Velazquez
Senior Director of Chemistry Abzena
Seminars
Wednesday 20th August 2025
Accelerating ADC Development and Manufacturing with ThioBridge™ Conjugation and Linker Technology
9:30 am
- ThioBridgeTM conjugation technology insights; how the technology works, and its advantages over stochastic conjugation technologies.
- Modulation of Drug-Antibody Ratio (DAR) using ThioBridge as effective feature to optimize therapeutic activity.
- In vitro and in vivo stability of ADCs generated using ThioBridgeTM
- Optimization of linker architecture to enhance in vivo efficacy of ThioBridgeTM ADCs. In vivo data for relevant ADCs generated using ThioBridgeTM technology
- ThioBridgeTM linker-payload and ADC manufacturing considerations.
