Marcello Marelli
Principal Scientist AstraZeneca
Seminars
Thursday 21st August 2025
Unlocking the ADC Toolbox: Stable Chemistry & Sites of Conjugation Combine to Improve Therapeutic Index
2:00 pm
- Stable conjugation chemistry and site of conjugation impact the stability of conjugates
- Long PKs increase tumor exposure and improve efficacy of ADC
- A move away from unstable thiol-maleimide conjugation chemistry and exposed conjugation sites will enable development of novel ADCs with improved therapeutic indices
