Tero Satomaa

Optimizing the DAR is crucial for achieving the balance between ADC stability and efficacy. This workshop will explore strategies for fine-tuning the DAR ratio to develop stable and efficacious ADCs, to improve clinical outcomes.

This workshop will cover:

• Understanding how hydrophobic payloads limit achievable DAR and strategies to mitigate this
• Leveraging moieties like phosphate prodrugs, PEGs, and charged amino acids to improve linker hydrophilicity and increase DAR
• Exploring the relationship between DAR, solubility, and off-target effects
• Balancing solvent selection, payload design, and conjugation strategies to achieve optimal DAR without compromising stability