8:55 am Chair’s Opening Remarks
Exploring Novel Conjugation Technologies to Widen the Possibilities for Early Design & Discovery
9:00 am Filtering Out Which Conjugation Technology to Use to Enhance Your ADCs Efficacy
Synopsis
- Evaluating which novel conjugation technology is the simplest and easiest to use
- Overviewing the novel conjugation technology landscape
- Comparing novel conjugation technologies to traditional ones
9:30 am Conjugation Technology-Enabled Solutions Broaden the Scope of Conjugatable Drugs
Synopsis
- Understanding how P5-labeling enables a rapid generation of stably linked, hydrophilic DAR8 ADCs from native antibodies
- Broadening the scope of drugs available for conjugation through novel Alco5-technology
- Outlining a superior linker-payload platform for the efficient and steady delivery of various drugs with different modes of actions
10:00 am Morning Networking Break
11:00 am Next-Generation Hydrophilic Click-Chemistry – Veraxa’s Selectable Site-Specific Bioconjugation
Synopsis
- Discussing the creation of selectable site-specific ADCs via incorporation of clickable non-canonical amino acids
- Overviewing the development of Veraxa’s hydrophilic click chemistry for bioconjugation
- Sharing Veraxa’s hydrophilic payload platform
11:30 am Harnessing Hinge-Region Disulfides for Homogenous DAR
Synopsis
- Outlining site-specific conjugation using hinge-region disulfides
- Developing a novel technology for homogenous DAR1
- Assessing the application to multiple ADCs and next-generation conjugates
12:00 pm Networking Lunch
1:00 pm Highlighting How the Mode of Conjugation Impacts Challenges During Bioconjugation & Resulting ADC Behavior
Synopsis
- Honing conjugation chemistries concerning the mAb to develop and advance conjugation technologies
- Understanding the relationship between ADC design and thermal and chemical/ metabolic stability
- Analyzing how to align linker and conjugation chemistries with each payload property
1:30 pm Roundtable Discussion: Assessing the Development of New Site-Specific Conjugation Platforms
Synopsis
- Develop new conjugation platform for the generation of site-specific ADCs
2:00 pm Analyzing the Impact of Linker-Payload Technologies on Early-Phase Development
Synopsis
- Understanding the impact of linker payload properties on ADC properties and linker payload and ADC manufacturing processes across development stages
- Discussing the impact of linker payloads on analytical profile and analytical development
- Reviewing the criticality of ADC properties and quality attributes for in vivo outcomes