Explore the Agenda
Workshop A
Identifying the Optimal Conjugation Site to Balance Stability & Payload Release
9:00 am Workshop A
Choosing the ideal conjugation site is critical for maximizing ADC stability and ensuring efficient release at the target site. This workshop will explore how
strategic conjugation site selection can enhance linker durability and improve ADC performance.
This workshop will cover:
- Understanding the influence of the chemical environment on conjugation site selection to improve hydrophobicity control
- Leveraging structural modeling and analytical tools to explore viable conjugation sites
- Balancing linker exposure to prevent premature cleavage while ensuring efficient release at the target site
- Exploring the impact of different conjugation chemistries (e.g., beta-glucuronidase, thiomaleimide) on site accessibility and stability
- Using hydrophobicity profiling and hydrophobic interaction chromatography to assess linker exposure
12:00 pm Lunch & Networking
Workshop B
Fine-Tuning Linker & Payload Design to Optimize DAR Without Compromising ADC Stability
1:00 pm Workshop B
Optimizing the DAR is crucial for achieving the balance between ADC stability and efficacy. This workshop will explore strategies for fine-tuning the DAR ratio to develop stable and efficacious ADCs, to improve clinical outcomes.
This workshop will cover:
- Understanding how hydrophobic payloads limit achievable DAR and strategies to mitigate this
- Leveraging moieties like phosphate prodrugs, PEGs, and charged amino acids to improve linker hydrophilicity and increase DAR
- Exploring the relationship between DAR, solubility, and off-target effects
- Balancing solvent selection, payload design, and conjugation strategies to achieve optimal DAR without compromising stability