Advancing Next Generation Hydrophilic Click Chemistry to Enhance ADC Selectivity & Therapeutic Index & Mitigate Off-Target Effects
- Understanding the advantages of the Veraxa hydrophilic click chemistry technology for enhancing ADC stability and pharmacokinetics while minimizing non-specific tissue uptake
- Showcasing reduction of off-target toxicity via charged payloads and tumor selective linkers to improve the therapeutic index and broaden the safety window for nextgeneration ADC therapies
- Increasing ADC selectivity by dual targeting bispecific ADCs via an End-Gate Approach to overcome tumor heterogeneity and mitigate on-target off-tumor toxicity for more precise cancer cell killing