Deploying Novel Linker Architectures to Improve Selectivity & Biophysical Properties of Novel Payloads
- Incorporating branched or linear carbohydrate polymers effectively masking high hydrophobicity and preventing ADC aggregation
- Exploring linkers with enzymatically cleavable triggers, for efficient tumor-localized payload release, to unlock the therapeutic novel payloads
- Understanding linker impact on payload delivery to explore extracellular release and internalizing peptides