Designing Branched Linkers for Dual Payload ADCs to Balance Synergy & Selectivity
- Investigating chemical engineering strategies for designing branch linkers for achieving distinct tumor-specific cleavage mechanisms
- Addressing challenges in maintaining payload stability and ensuring effective payload release while preserving the overall functionality of the ADC
- Exploring the use of modified conjugation methods to achieve controlled ratios of each payload, ensuring synergistic effects without compromising safety or efficacy