Focusing on the high-value challenge of improving established cytotoxins, this hands-on workshop tackles the "why now" of evolving chemistry for traditional payloads. Providing a tactical playbook for leveraging next-generation linker design and site-specific conjugation to overcome the limitations of first-generation ADCs and achieve best-inclass profiles.

This is a must-attend for teams looking to maximum the value of proven payloads by understanding that where you attach is as important as what you attach by:

This workshop will gather experts to discuss:

• Systematically evaluating how strategic changes to the conjugation site impact critical attributes such as antibody stability, antigen binding, and off-target toxicity profiles
• Benchmarking novel linker designs, from peptide-based to hydrophilic polymer shields to assess their ability to improve solubility, reduce aggregation, and enable higher DARs without compromising tolerability in traditional payloads.
• Building a comparative case study on site-specific vs. stochastic conjugation for a traditional payload, analyzing hard data on homogeneity, pharmacokinetic consistency, and manufacturability to justify the investment in advanced conjugation technologies