Harnessing Traceless Linker Design & Site-Specific Conjugation to Overcome Degrader-Driven Hydrophobicity & Enable Next-Generation Degrader-Antibody Conjugates
- Advancing beyond traditional ADC linker paradigms with proprietary traceless, site-specific conjugation chemistry that enables stable attachment of cereblonbased degraders while preserving intrinsic payload structure and improving overall conjugate solubility
- Engineering hydrophilicity directly into linker architecture through modular, water-solubilizing elements and conditional intracellular release triggers to systematically mitigate degrader-driven hydrophobicity and reduce aggregation risk
- Leveraging linker–conjugation integration within the PROTAb platform to achieve controlled intracellular release, molecular homogeneity, and biophysical stability, unlocking Degrader-Antibody Conjugates capable of targeting undruggable proteins