Utilizing Enzymatic Conjugation through Transglutaminases for Chemo- Selective, Homogeneous Attachment at Engineered Sequence Sites to Maintain Native Antibody Integrity and In Vivo Circulatory Half-Life
- Using peptide-based affinity tags and native transglutaminase to achieve chemoselective, covalent conjugation exclusively at engineered glutamine residues enabling homogeneous, site-specific bioconjugation
- Leveraging innate specificity of enzymatic catalysis for peptide substrates, to drive the conjugation reaction with high fidelity and efficiency, ensuring a homogeneous DAR product with minimal by-products
- Using Therano-Sticktm to conjugate antibody fragments and improve the therapeutic index