Anokha Ratnayake
Seminars
The future of antibody-drug conjugates is accelerating beyond traditional cytotoxic payloads, fueled by rapid innovation in linker engineering, novel conjugation platforms, and the integration of computational biology. As converging technologies redefine what an ADC can deliver, the antibody is evolving into a versatile delivery vehicle capable of transporting an increasingly diverse therapeutic arsenal.
This session explores the feasibility and promise of emerging payload classes, the transformation of the linker from a
passive connector into an active, programmable controller of drug release, and strategies for designing molecules that are translatable and manufacturable from day one.
Join this panel to gain strategic foresight on positioning your ADC programs at the forefront of targeted oncology and beyond by discussing:
- Exploring the transition beyond cytotoxins to integrate degraders, radio nuclides, and immune modulators, focusing on the radical linker and conjugation innovations required to expand the ADC therapeutic arsenal into new disease spaces
- Debating the future role of the linker as a smart, stimuli-responsive "payload traffic controller", evaluating emerging
- technologies to achieve maximal tumor killing with minimal systemic exposure for an optimized therapeutic window
- Strategizing to build future-proof platforms that integrate predictive in silico modelling of biophysical properties with scalable site-specific conjugation, to de-risk development timelines and accelerate the delivery of next-generation ADCs to patients
Focusing on the high-value challenge of improving established cytotoxins, this hands-on workshop tackles the "why now" of evolving chemistry for traditional payloads. Providing a tactical playbook for leveraging next-generation linker design and site-specific conjugation to overcome the limitations of first-generation ADCs and achieve best-inclass profiles.
This is a must-attend for teams looking to maximum the value of proven payloads by understanding that where you attach is as important as what you attach by:
This workshop will gather experts to discuss:
- Systematically evaluating how strategic changes to the conjugation site impact critical attributes such as antibody stability, antigen binding, and off-target toxicity profiles
- Benchmarking novel linker designs, from peptide-based to hydrophilic polymer shields to assess their ability to improve solubility, reduce aggregation, and enable higher DARs without compromising tolerability in traditional payloads.
- Building a comparative case study on site-specific vs. stochastic conjugation for a traditional payload, analyzing hard data on homogeneity, pharmacokinetic consistency, and manufacturability to justify the investment in advanced conjugation technologies
