Jagath Reddy Junutula
Seminars
Thursday 30th July 2026
Implementing Hydrophilic Sugar-Based Linker Spacers to Shield Hydrophobic Payloads & Minimize Antibody Aggregation for Enhanced Serum Stability
9:30 am
- Incorporating flexible, hydrophilic chains directly on linker cores to create a dynamic solubility shield around the hydrophobic payload, prevent both intermolecular aggregation and non-specific hydrophobic interactions
- Integrating modules into the linker design to leverage innate hydrophilicity and biocompatibility, significantly improving the aqueous solubility and biophysical profile of the entire ADC
- Designing linkers with charged groups to fine-tune the overall hydrophilic-lipophilic balance of the conjugate optimizing its serum stability
