Marco Lobba
CEO Catena Biosciences
Seminars
Tuesday 19th August 2025
Workshop A
9:00 am
Choosing the ideal conjugation site is critical for maximizing ADC stability and ensuring efficient release at the target site. This workshop will explore how
strategic conjugation site selection can enhance linker durability and improve ADC performance.
This workshop will cover:
- Understanding the influence of the chemical environment on conjugation site selection to improve hydrophobicity control
- Leveraging structural modeling and analytical tools to explore viable conjugation sites
- Balancing linker exposure to prevent premature cleavage while ensuring efficient release at the target site
- Exploring the impact of different conjugation chemistries (e.g., beta-glucuronidase, thiomaleimide) on site accessibility and stability
- Using hydrophobicity profiling and hydrophobic interaction chromatography to assess linker exposure
Wednesday 20th August 2025
Next-Generation Multi-Payload ADCs: How Site-Selective Conjugations Enable New Modalities
9:00 am
- Potential of dual-payload ADCs and challenges presented by traditional conjugation approaches
- Review of approaches to manufacturing dual-payload ADCs, with focus on the CysTyr platform for site-specific conjugation
- Efficacy of Multi-Payload Conjugates produced using CysTyr conjugation
