Sampat Ingale
Seminars
Wednesday 29th July 2026
Glycan-Directed, Site-Specific Conjugation Strategies to Enable Homogeneous Dual-Payload ADCs with Tunable Effector Function & Optimized Therapeutic Index
1:30 pm
- Leveraging conserved Fc N-glycans and orthogonal conjugation chemistries to create spatially defined attachment sites for dual payload incorporation, enabling homogeneous, structurally stable ADCs Fc integrity, and pharmacokinetic performance
- Integrating highly stable, irreversible linker technologies with controlled DAR to independently modulate two mechanistically distinct payloads, minimizing premature release, reducing systemic toxicity, and maintaining payload balance
- Applying Biohaven’s MATE™ platform and advanced conjugation strategy to nextgeneration programs such as BHV-1510 and BHV-1530, supporting dual-payload designs that combine synergistic cytotoxic mechanisms, improved safety margins, and enhanced anti-tumor durability
