Pre-Conference Workshop Day
Tuesday | August 22, 2023
Linker 101- Examining the Importance of Linker Stability
- Marc-André Kasper Director, Chemistry & Early Discovery, Tubulis
With an increasing abundance of ADCs entering preclinical and clinical studies, the amount of information ADC developers are collecting about when to use what linker is growing. Additionally, as the ADC design toolkit expands, selecting the right linker for your desired ADC is becoming a key strategic design talking point.
Attending this workshop will provide a high-level overview of the current linker technologies available to enable you to:
• Learn the basics of linker chemistry and examine how it can be modified to create a linker with optimal properties for you desired outcome
• Understand why selecting the correct linker is integral to your ADC’s success, and evaluate the advantages of using different linkers in different settings
• Compare and contrast cleavable and non-cleavable linkers and analyze how payload choice affects your linker choice
12:00 pm Networking Lunch
Delving Into Site-Specific Conjugations to Create Homogenous ADCs
- Nathan Tumey Assistant Professor, Binghampton University
- Sayumi Yamazoe Senior Principal Scientist, Bristol Myers Squibb
In the last two years, the proportion of clinically site-specific ADC has increased from 23% to 29%*, and novel site-specific conjugation technologies have overtaken traditional cysteine-based site-specific ADCs.
This has given food for thought to ADC developers on what conjugation strategies to employ. It has also made assessing the advantages of site-specific conjugation versus stochastic conjugation, and evaluating different site-specific technologies against themselves a core decision on ADC design.
Attending this workshop will enable you to:
• Discuss the advantages of site-specific conjugation against stochastic conjugation
• Evaluate the different types of site-specific conjugation and which combinations of payload, linker, antibody and target are most amenable to each type
• Analyze conjugation chemistries and examine fundamental process and manufacturing challenges
* According to Beacon Targeted Therapies Data