Deploying Novel Linker Architectures to Improve Selectivity & Biophysical Properties of Novel Payloads

• Incorporating branched or linear carbohydrate polymers effectively masking high hydrophobicity and preventing ADC aggregation
• Exploring linkers with enzymatically cleavable triggers, for efficient tumor-localized payload release, to unlock the therapeutic novel payloads
• Understanding linker impact on payload delivery to explore extracellular release and internalizing peptides

Speakers:

Robert Lutz

Chief Scientific Officer

Iksuda Therapeutics